Pulmonary alveolar proteinosis in association with Fanconi's anemia and psoriasis. A possible common pathogenetic mechanism

Chest. 1992 Aug;102(2):637-8. doi: 10.1378/chest.102.2.637.


We report a case of PAP which proved to be fatal despite whole lung lavage. The need for early BAL and transbronchial biopsies in diffuse infiltrative lung disorders of unknown etiology is highlighted. The occurrence of PAP in association with Fanconi's anemia and psoriasis raises the possibility of a common pathogenetic defect which may be related to abnormal cytokine metabolism. Investigation of cytokine metabolism in PAP is warranted.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Bronchi / pathology
  • Bronchoalveolar Lavage Fluid / cytology
  • Bronchoalveolar Lavage Fluid / microbiology
  • Fanconi Anemia / diagnosis
  • Fanconi Anemia / etiology*
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Mycetoma / diagnosis
  • Opportunistic Infections / diagnosis
  • Pseudallescheria / isolation & purification
  • Psoriasis / diagnosis
  • Psoriasis / etiology*
  • Pulmonary Alveolar Proteinosis / diagnosis
  • Pulmonary Alveolar Proteinosis / etiology*
  • Radiography