Characteristics of the 'metabolic syndrome X' in a cardiovascular low risk population in Crete

Eur Heart J. 1992 Jul;13(7):865-71. doi: 10.1093/oxfordjournals.eurheartj.a060284.


We have studied hypertension, obesity, diabetes and hypercholesterolaemia in those aged 45-79 years in the Cretan low risk population of Spili (n = 249; attendance 82%) to see if these conditions interacted in the same way as previously described for high risk populations. Hypertension, diabetes, obesity, and hypercholesterolaemia were found to be at least as prevalent in Spili as in Sweden. Furthermore, the previously described 'Metabolic Syndrome X', with insulin resistance and hyperinsulinaemia as a common denominator also seemed to exist in the Spili population where patients with these conditions had higher insulin and C-peptide levels than normals. Our finding should be viewed against the low prevalence of past myocardial infarction in Cretan men from Spili reported by us and confirming the results of the Seven Countries Study.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Coronary Disease / epidemiology*
  • Coronary Disease / etiology
  • Cross-Cultural Comparison*
  • Cross-Sectional Studies
  • Diabetes Complications
  • Diabetes Mellitus / epidemiology*
  • Female
  • Greece / epidemiology
  • Humans
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / epidemiology*
  • Hypertension / complications
  • Hypertension / epidemiology*
  • Incidence
  • Lipids / blood
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / etiology
  • Obesity / complications
  • Obesity / epidemiology*
  • Risk Factors


  • Lipids