Suboptimal glycemic control, independently of QT interval duration, is associated with increased risk of ventricular arrhythmias in a high-risk population

Pacing Clin Electrophysiol. 2006 Jan;29(1):9-14. doi: 10.1111/j.1540-8159.2006.00298.x.


Background: Although cardiovascular disease is the leading cause of mortality in diabetic patients, little is known about the impact of glycemic control on ventricular tachycardia (VT).

Objective: To investigate whether hemoglobin A1c (HbA1c) is associated with increased incidence of VT.

Methods: A retrospective study of 336 implantable cardioverter-defibrillator patients (both diabetes mellitus (DM) and non-DM) was conducted.

Results: HbA1c levels between 8% and 10% had a significant association with spontaneous VT, but not with QT/QTc.

Conclusions: Glycemic index is a significant predictor of spontaneous VT, independently of QT interval. Optimal glycemic control may help reduce occurrence of VT and sudden cardiac death in high-risk DM patients.

MeSH terms

  • Aged
  • Chi-Square Distribution
  • Defibrillators, Implantable
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Electrocardiography
  • Glycated Hemoglobin A / analysis
  • Glycemic Index
  • Humans
  • Hyperglycemia / complications*
  • Hyperglycemia / physiopathology*
  • Logistic Models
  • Male
  • Retrospective Studies
  • Statistics, Nonparametric
  • Tachycardia, Ventricular / etiology*
  • Tachycardia, Ventricular / physiopathology*
  • Tachycardia, Ventricular / therapy


  • Glycated Hemoglobin A