The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease

Am J Cardiol. 2006 Jan 16;97(2A):3A-11A. doi: 10.1016/j.amjcard.2005.11.010. Epub 2005 Dec 5.


There is accumulating evidence that inflammation is an important risk factor in cardiovascular disease (CVD). Elevated levels of the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk for CVD and diabetes mellitus. Adding hs-CRP to the definition of the metabolic syndrome has been shown to improve the prediction of CVD. Elevated hs-CRP levels may also be predictive of development of the metabolic syndrome. Current definitions of the metabolic syndrome differ, and cardiovascular risk appears to differ according to which component risk factors are present. Further studies are required to identify a widely accepted criterion for the syndrome that will optimally predict the risk of diabetes and CVD. It is possible that such a definition will include a measure of inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology*
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / etiology*
  • Humans
  • Inflammation / blood
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / complications*
  • Risk Factors


  • Biomarkers
  • C-Reactive Protein