Inflammation in renal disease

Am J Cardiol. 2006 Jan 16;97(2A):20A-27A. doi: 10.1016/j.amjcard.2005.11.012. Epub 2005 Dec 1.


Inflammation is a component of the major modifiable risk factors in renal disease. Elevated high-sensitivity C-reactive protein (hs-CRP) levels have been shown to predict all-cause and cardiovascular mortality in patients dependent on dialysis and to predict worsening renal function in subjects without overt renal disease. Levels of hs-CRP are also predictive of hypertension, a major risk factor for renal disease, across all levels of blood pressure in subjects without initial hypertension. Many of the treatments used in patients with renal disease exert anti-inflammatory activities that constitute or contribute to their therapeutic effects. A number of studies have indicated that statin therapy exerts a renoprotective effect that is possibly mediated by anti-inflammatory activities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology*
  • Global Health
  • Humans
  • Incidence
  • Inflammation / blood
  • Kidney Diseases / blood
  • Kidney Diseases / complications*
  • Risk Factors
  • Survival Rate


  • Biomarkers
  • C-Reactive Protein