Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain

Hironori Katoh; Satoshi Fujimoto; Chisaki Ishida; Yukio Ishikawa; Manabu Negishi

doi:10.1016/j.brainres.2005.12.085

Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain

Brain Res. 2006 Feb 16:1073-1074:103-8. doi: 10.1016/j.brainres.2005.12.085. Epub 2006 Jan 27.

Authors

Hironori Katoh¹, Satoshi Fujimoto, Chisaki Ishida, Yukio Ishikawa, Manabu Negishi

Affiliation

¹ Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan. hirokato@pharm.kyoto-u.ac.jp

PMID: 16443196
DOI: 10.1016/j.brainres.2005.12.085

Abstract

ELMO is an upstream regulator of the Rho family small GTPase Rac. We investigated the distributions of mRNAs of two subtypes of ELMO, ELMO1 and ELMO2, in the developing mouse brain. Both ELMO1 and ELMO2 mRNAs are widely distributed in the developing mouse brain, but they were expressed in different neuronal populations in the cerebral cortex, thalamus, and cerebellum. Thus, ELMO1 and ELMO2 may play different roles during brain development.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Animals, Newborn
Brain / enzymology
Brain / growth & development
Brain / metabolism*
Cytoskeletal Proteins / genetics
Cytoskeletal Proteins / metabolism*
Embryo, Mammalian
Gene Expression / physiology
In Situ Hybridization / methods
Mice
RNA, Messenger / metabolism*
Reverse Transcriptase Polymerase Chain Reaction / methods

Substances

Adaptor Proteins, Signal Transducing
Cytoskeletal Proteins
ELMO1 protein, mouse
RNA, Messenger