Pattern of prolactin secretion after administration of gonadotropin-releasing hormone agonist at the preovulatory phase of intrauterine insemination cycles

Sao Paulo Med J. 2005 Nov 3;123(6):295-7. doi: 10.1590/s1516-31802005000600010. Epub 2006 Jan 20.

Abstract

Context and objective: Administration of a gonadotropin-releasing hormone (GnRH) agonist at the preovulatory phase is an option for triggering ovulation in assisted reproductive technology cycles. The aim of this work was to investigate the pattern of prolactin secretion after the administration of a single dose of GnRH-agonist at the preovulatory phase.

Design and setting: Descriptive study at a tertiary referral center.

Participants: Fifteen normally ovulating patients undergoing ovarian stimulation for intrauterine insemination were studied.

Methods: Ovarian stimulation was carried out using human menopausal gonadotropin (intramuscular 75 IU daily). When at least one follicle reached 17 mm (observed echographically), 0.5 mg of buserelin acetate was administered. Blood samples were taken to determine prolactin concentrations, at the time of agonist injection and 4, 8, 12, 24 and 48 hours later.

Results: A statistically significant increase in serum levels of prolactin was observed 4, 8 and 12 hours after GnRH-agonist administration, with a peak at 8 hours.

Conclusion: The administration of a single dose of GnRH-agonist at the preovulatory phase in patients undergoing ovarian stimulation performed with human menopausal gonadotropin causes a significant increase in serum prolactin levels.

MeSH terms

  • Adult
  • Female
  • Gonadotropin-Releasing Hormone / administration & dosage*
  • Gonadotropin-Releasing Hormone / agonists
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Humans
  • Menopause
  • Ovarian Follicle / drug effects
  • Ovulation Induction / methods*
  • Prolactin / blood
  • Prolactin / metabolism*

Substances

  • Gonadotropin-Releasing Hormone
  • Prolactin