'Hy's law,' the 'Rezulin Rule,' and other predictors of severe drug-induced hepatotoxicity: putting risk-benefit into perspective

Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):221-9. doi: 10.1002/pds.1209.
No abstract available

MeSH terms

  • Alanine Transaminase / blood
  • Anticoagulants / adverse effects
  • Azetidines / adverse effects
  • Benzylamines / adverse effects
  • Bilirubin / blood
  • Biomarkers / blood
  • Chemical and Drug Induced Liver Injury / blood
  • Chemical and Drug Induced Liver Injury / enzymology
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chromans / adverse effects*
  • Drug Approval
  • Humans
  • Hypoglycemic Agents / adverse effects*
  • Jaundice / blood
  • Jaundice / enzymology
  • Jaundice / etiology
  • Liver / drug effects*
  • Liver / enzymology
  • Liver Failure, Acute / blood
  • Liver Failure, Acute / enzymology
  • Liver Failure, Acute / etiology*
  • Pharmacoepidemiology / trends
  • Predictive Value of Tests
  • Risk Assessment
  • Thiazolidinediones / adverse effects*
  • Troglitazone
  • United States
  • United States Food and Drug Administration

Substances

  • Anticoagulants
  • Azetidines
  • Benzylamines
  • Biomarkers
  • Chromans
  • Hypoglycemic Agents
  • Thiazolidinediones
  • ximelagatran
  • Alanine Transaminase
  • Troglitazone
  • Bilirubin