Abstract
Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis of these inhibitors.
MeSH terms
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Arginine / analogs & derivatives*
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Arginine / blood
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Arginine / metabolism
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Arginine / pharmacology
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Enzyme Inhibitors / blood
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology
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Humans
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Nitric Oxide Synthase / antagonists & inhibitors
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Protein-Arginine N-Methyltransferases / genetics
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Protein-Arginine N-Methyltransferases / metabolism
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Renal Insufficiency / blood
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omega-N-Methylarginine / metabolism
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omega-N-Methylarginine / pharmacology
Substances
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Enzyme Inhibitors
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Isoenzymes
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omega-N-Methylarginine
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N,N-dimethylarginine
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Arginine
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Nitric Oxide Synthase
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Protein-Arginine N-Methyltransferases