Endogenous production of nitric oxide synthase inhibitors

Vasc Med. 2005 Jul:10 Suppl 1:S3-9. doi: 10.1191/1358863x05vm595oa.

Abstract

Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis of these inhibitors.

Publication types

  • Review

MeSH terms

  • Arginine / analogs & derivatives*
  • Arginine / blood
  • Arginine / metabolism
  • Arginine / pharmacology
  • Enzyme Inhibitors / blood
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Protein-Arginine N-Methyltransferases / genetics
  • Protein-Arginine N-Methyltransferases / metabolism
  • Renal Insufficiency / blood
  • omega-N-Methylarginine / metabolism
  • omega-N-Methylarginine / pharmacology

Substances

  • Enzyme Inhibitors
  • Isoenzymes
  • omega-N-Methylarginine
  • N,N-dimethylarginine
  • Arginine
  • Nitric Oxide Synthase
  • Protein-Arginine N-Methyltransferases