[Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient]

Rinsho Ketsueki. 2005 May;46(5):363-7.
[Article in Japanese]


A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adenoviridae Infections*
  • Administration, Oral
  • Anemia, Aplastic / therapy
  • Antiviral Agents / administration & dosage*
  • Female
  • Graft vs Host Disease / prevention & control
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Lymphohistiocytosis, Hemophagocytic / drug therapy*
  • Lymphohistiocytosis, Hemophagocytic / virology*
  • Middle Aged
  • Opportunistic Infections*
  • Peripheral Blood Stem Cell Transplantation / adverse effects*
  • Ribavirin / administration & dosage*
  • Treatment Outcome


  • Antiviral Agents
  • Immunosuppressive Agents
  • Ribavirin