The influence of HIV infection on the correlation between plasma concentrations of monocyte chemoattractant protein-1 and carotid atherosclerosis

Clin Chim Acta. 2006 Jun;368(1-2):114-9. doi: 10.1016/j.cca.2005.12.014. Epub 2006 Jan 30.


Background: Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in atherosclerosis and it has been recently proposed as a surrogate biomarker of long-term clinical outcomes in patients with acute myocardial infarction. Little is known of the factors that may influence plasma MCP-1 concentrations.

Methods: We studied 384 healthy volunteers and 226 HIV-infected patients as a model of chronic inflammatory condition that predisposes to sub-clinical atherosclerosis.

Results: In healthy participants there were significant associations between plasma MCP-1 concentration and age, smoking status, and serum triglyceride concentrations that were not observed in the HIV-infected patients. The plasma concentration of MCP-1 was significantly associated with the polymorphism at position -2518 of the MCP-1 gene and, in patients, with the carotid artery intima-media thickness. There were also significant correlations indicating a close association between MCP-1 and HIV disease activity. However, in a multiple regression model, only age, the MCP-1 genotype and smoking status showed significant, and independent, associations with plasma MCP-1 concentrations.

Conclusion: Plasma MCP-1 concentration is genetically determined and associated with age and smoking habit and it also correlates with subclinical atherosclerosis in HIV-infected patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Chemokine CCL2 / blood*
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / complications*
  • Coronary Artery Disease / genetics
  • Coronary Artery Disease / pathology
  • Female
  • Genotype
  • HIV / physiology*
  • HIV Infections / blood*
  • HIV Infections / complications*
  • HIV Infections / genetics
  • HIV Infections / virology
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics
  • Receptors, CCR2
  • Receptors, Chemokine / genetics
  • Risk Factors


  • CCR2 protein, human
  • Chemokine CCL2
  • Receptors, CCR2
  • Receptors, Chemokine