Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development

Gene Expr Patterns. 2006 Jun;6(5):556-65. doi: 10.1016/j.modgep.2005.10.005. Epub 2006 Jan 30.


During development of vertebrate embryos, retinoic acid plays a variety of roles that are mediated by binding to retinoic acid receptors (Rars) and their heterodimerization partners, the retinoid receptors (Rxrs). Here, we characterize the expression patterns of four zebrafish rxr genes during development and provide an analysis of the phylogenetic relationships between zebrafish and tetrapod Rxr genes based on sequence similarities and conserved syntenies. This analysis prompted the renaming of several of the zebrafish rxr genes to match their tetrapod orthologs. Understanding phylogenetic relationships among Rxr genes and their expression patterns during development provides a foundation for future studies of Rxr functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA Primers
  • Female
  • Gene Expression Profiling
  • In Situ Hybridization
  • Phylogeny
  • Retinoid X Receptors / genetics*
  • Zebrafish / embryology*
  • Zebrafish / genetics*


  • DNA Primers
  • Retinoid X Receptors