Cannabis withdrawal among non-treatment-seeking adult cannabis users

Am J Addict. Jan-Feb 2006;15(1):8-14. doi: 10.1080/10550490500418997.


This study investigates the clinical significance of a cannabis withdrawal syndrome in 104 adult, non-treatment-seeking, primarily cannabis users who reported at least one serious attempt to stop using cannabis. Retrospective self-report data were obtained on eighteen potential cannabis withdrawal symptoms derived from the literature, including co-occurrence, time course, and any actions taken to relieve the symptom. Study findings provide evidence for the clinical significance of a cannabis withdrawal syndrome, based on the high prevalence and co-occurrence of multiple symptoms that follow a consistent time course and that prompt action by the subjects to obtain relief, including serving as negative reinforcement for cannabis use.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Alcohol Drinking / epidemiology
  • Cannabinoids / adverse effects*
  • Comorbidity
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Marijuana Abuse / rehabilitation*
  • Middle Aged
  • Patient Acceptance of Health Care
  • Recurrence
  • Self Care* / psychology
  • Smoking / epidemiology
  • Substance Withdrawal Syndrome / diagnosis
  • Substance Withdrawal Syndrome / epidemiology
  • Substance Withdrawal Syndrome / etiology*
  • Substance Withdrawal Syndrome / psychology
  • Tranquilizing Agents / administration & dosage


  • Cannabinoids
  • Tranquilizing Agents