Opioid analgesia in persons at risk for hypertension

Psychosom Med. 2006 Jan-Feb;68(1):116-20. doi: 10.1097/01.psy.0000195742.24850.79.


Objective: Acute pain sensitivity is reduced in clinical hypertension, but the precise relationship between pain perception and altered blood pressure control is not well-characterized. A negative correlation between resting blood pressure and pain sensitivity is observed throughout the normotensive range, suggesting links between basic mechanisms of blood pressure control and pain regulation. The opioid peptides are important endogenous analgesic mechanisms, but their role in the hypoalgesia of blood pressure elevations has not been well-established. The current study sought to examine the effects of endogenous opioids on blood pressure-associated hypoalgesia in young adults at risk for hypertension development.

Methods: The effects of the opioid receptor antagonist, naltrexone, on cold pressor pain sensitivity were assessed in young adult men (n = 49) and women (n = 76) with mildly elevated casual blood pressure.

Results: Results indicate interactions between hypertension risk and the effects of opioid blockade on pain sensitivity.

Conclusions: These findings suggest exaggerated opioid analgesia in persons at enhanced risk for hypertension and point to important links between altered neuropeptide regulation of pain and altered blood pressure control mechanisms in the early stages of hypertension.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Cold Temperature
  • Female
  • Humans
  • Hypertension / physiopathology*
  • Hypesthesia / physiopathology
  • Male
  • Naltrexone / pharmacology*
  • Narcotic Antagonists / pharmacology*
  • Opioid Peptides / physiology*
  • Pain / physiopathology*
  • Pain Threshold / drug effects
  • Pain Threshold / physiology
  • Risk


  • Narcotic Antagonists
  • Opioid Peptides
  • Naltrexone