Lanthanum carbonate

Ann Pharmacother. 2006 Feb;40(2):234-40. doi: 10.1345/aph.1G224. Epub 2006 Jan 31.


Objective: To review the pharmacology, pharmacokinetics, clinical efficacy, and safety profile of lanthanum carbonate, a phosphate binder for chronic kidney disease (CKD).

Data sources: Information was selected from PubMed (1965-October 2005). All studies presented as scientific posters and abstracts from nephrology meetings from 1999 to 2005 were also included.

Study selection and data extraction: All published articles regarding lanthanum carbonate were included. In addition, abstracts and presentations from scientific meeting symposia were also considered for inclusion.

Data synthesis: Lanthanum carbonate has been recently approved as non-calcium-based therapy for phosphate reduction in patients with stage 5 CKD requiring dialysis. The recommended dose is 250-500 mg with meals, for a maximum of 1500 mg daily. Clinical studies have shown short- and long-term safety with lanthanum carbonate administration. Adverse effects were primarily gastrointestinal in nature. Clinical trials have also shown reductions in serum phosphorus to target concentrations, reductions in associated calcium-phosphorus product, and minimal effects on serum calcium and parathyroid hormone concentrations.

Conclusions: Lanthanum carbonate is an effective phosphate-binding agent without significant risk of hypercalcemia or worsening metabolic acidosis. Lanthanum carbonate is a safe and effective drug for reduction of elevated serum phosphorus levels associated with stage 5 CKD. The role of lanthanum carbonate relative to other phosphate-binding drugs, such as calcium salts and sevelamer, remains to be determined.

Publication types

  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Clinical Trials as Topic
  • Humans
  • Kidney Diseases / blood
  • Kidney Diseases / drug therapy*
  • Lanthanum* / adverse effects
  • Lanthanum* / pharmacokinetics
  • Lanthanum* / pharmacology
  • Lanthanum* / therapeutic use
  • Phosphorus / blood
  • Treatment Outcome


  • Phosphorus
  • lanthanum carbonate
  • Lanthanum