Inhibition of immune responses by ITAM-bearing receptors

Sci STKE. 2006 Jan 31;2006(320):re1. doi: 10.1126/stke.3202006re1.

Abstract

Cells of the immune system possess many multisubunit receptors that are composed of a ligand-binding subunit associated with distinct signaling adaptors containing one or more immunoreceptor tyrosine-based activation motifs (ITAMs). These receptors include the T cell receptor, the B cell receptor, and many Fc receptors, as well as families of activating receptors on myeloid and natural killer cells. Receptors that associate with ITAM-containing adaptors classically have been viewed as transducing activating signals involving phosphorylation of the tyrosines within the ITAM and recruitment of Syk family tyrosine kinases. Receptors associated with ITAM-containing adaptors in myeloid cells have also been implicated in inhibition of cellular activation. Here, we discuss these new negative roles for signaling by receptors that associate with ITAM-bearing adaptors in myeloid and other cell types within the immune system.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / deficiency
  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / physiology
  • Amino Acid Motifs*
  • Animals
  • Antigens, CD / physiology
  • Calcium Signaling
  • Cell Differentiation
  • Cytokines / metabolism
  • Enzyme Precursors / physiology*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Lymphocytes / immunology*
  • Macrophage Activation
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Biological
  • Myeloid Cells / immunology*
  • Phosphorylation
  • Phosphotyrosine / physiology
  • Protein Processing, Post-Translational / physiology*
  • Protein Tyrosine Phosphatases / physiology
  • Protein-Tyrosine Kinases / physiology*
  • Receptors, Antigen, B-Cell / chemistry
  • Receptors, Antigen, B-Cell / immunology
  • Receptors, Antigen, T-Cell / chemistry
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Fc / chemistry
  • Receptors, Fc / immunology
  • Receptors, Fc / physiology
  • Receptors, IgG / physiology
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / physiology*
  • Signal Transduction / physiology*
  • Syk Kinase
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology
  • ZAP-70 Protein-Tyrosine Kinase / physiology*
  • src Homology Domains

Substances

  • Adaptor Proteins, Signal Transducing
  • Antigens, CD
  • Cytokines
  • Enzyme Precursors
  • Fc(alpha) receptor
  • Intracellular Signaling Peptides and Proteins
  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell
  • Receptors, Fc
  • Receptors, IgG
  • Receptors, Immunologic
  • Tyrobp protein, mouse
  • Phosphotyrosine
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • Syk protein, mouse
  • ZAP-70 Protein-Tyrosine Kinase
  • Protein Tyrosine Phosphatases