MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall

J Bacteriol. 2006 Feb;188(4):1660-2. doi: 10.1128/JB.188.4.1660-1662.2006.

Abstract

MurQ is an N-acetylmuramic acid-phosphate (MurNAc-P) etherase that converts MurNAc-P to N-acetylglucosamine-phosphate and is essential for growth on MurNAc as the sole source of carbon (T. Jaegar, M. Arsic, and C. Mayer, J. Biol. Chem. 280:30100-30106, 2005). Here we show that MurQ is the only MurNAc-P etherase in Escherichia coli and that MurQ and AnmK kinase are required for utilization of anhydro-MurNAc derived either from cell wall murein or imported from the medium.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Wall / metabolism
  • Culture Media / metabolism
  • Escherichia coli / enzymology*
  • Escherichia coli / growth & development
  • Escherichia coli Proteins / metabolism*
  • Glycoside Hydrolases / metabolism*
  • Muramic Acids / metabolism*

Substances

  • Culture Media
  • Escherichia coli Proteins
  • Muramic Acids
  • anhydro-N-acetylmuramic acid
  • Glycoside Hydrolases
  • MurQ protein, E coli