[Alveolar haemorrhage and hepatitis virus C related mixed cryoglobulinemia. Report of three cases]

An Med Interna. 2005 Nov;22(11):529-31. doi: 10.4321/s0212-71992005001100006.
[Article in Spanish]


Hepatitis C virus -related mixed cryoglobulinemia is a recognised entity. Renal and pulmonary involvements are severe potential complications of this disease. Alveolar haemorrhage is a form of pulmonary complication. The clinical features of the alveolar haemorrhage can mimic other pulmonary diseases. We present three patients with hepatitis C virus-related mixed cryoglobulinemia associated to pulmonary symptoms that turned to be caused by an alveolar haemorrhage. The first patient was a 71-year old woman that was admitted because of hemoptysis and severe dyspnea that required mechanical ventilation. Although a pneumonia was the initial diagnoses, an alveolar haemorrhage was soon suspected based on the persistence of the pulmonary radiological infiltrates despite an adequate empirical antibiotic treatment and the presence of a progressive anemization. A fibrobronchoscopy, performed 48 hours after treatment was begun, revealed the presence of a 6% of hemosiderophages. The second patient was a 64 years old woman admitted because of dyspnea, vasculitic cutaneous lesions in gluteus and kidney failure. A severe pneumonia was suspected, antibiotic treatment was started and again the patient needed mechanical ventilation. The fibrobronchoscopy demonstrated the existence of a 60% of hemosiderophages. The third case describes a 67 year old woman that complained of fever, dyspnea and right chest pain. Similarly to the previous cases a severe pneumonia was the initial diagnoses, the patient needed to be transferred to the intensive care unit and mechanical ventilation was finally required. The fibrobronchoscopy showed remains of blood suggestive of an alveolar haemorrhage.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Cryoglobulinemia / complications*
  • Cryoglobulinemia / virology
  • Female
  • Hemoptysis / etiology*
  • Hemorrhage / etiology
  • Hepacivirus
  • Hepatitis C / complications*
  • Humans
  • Lung Diseases / etiology
  • Middle Aged
  • Pulmonary Alveoli*