Cellular senescence in aging primates

Science. 2006 Mar 3;311(5765):1257. doi: 10.1126/science.1122446. Epub 2006 Feb 2.

Abstract

The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very old individuals. In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging / physiology*
  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Biomarkers
  • Cell Cycle Proteins / metabolism
  • Cellular Senescence / physiology*
  • DNA Damage
  • DNA Replication
  • DNA-Binding Proteins / metabolism
  • Dermis / cytology
  • Female
  • Fibroblasts / cytology
  • Fibroblasts / physiology*
  • Heterochromatin / metabolism
  • Male
  • Oxidative Stress
  • Papio / physiology*
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction
  • Telomere / physiology
  • Tumor Suppressor Proteins / metabolism

Substances

  • Biomarkers
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Heterochromatin
  • Tumor Suppressor Proteins
  • Ataxia Telangiectasia Mutated Proteins
  • Protein-Serine-Threonine Kinases