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Review
, 98 (2), 186-91

Early Growth response-1 in Cardiovascular Pathobiology

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Review

Early Growth response-1 in Cardiovascular Pathobiology

Levon M Khachigian. Circ Res.

Abstract

The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amazing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.

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