A prospective study comparing oral sodium phosphate solution to a bowel cleansing preparation with nutrition food package in children

J Pediatr Gastroenterol Nutr. 2006 Feb;42(2):174-7. doi: 10.1097/01.mpg.0000189353.40419.31.


Objective: The inability of children to comply with bowel preparation regimens can result in inadequate visualization of the colon. This study compares the safety, efficacy, and patient acceptance of a prepackaged diet kit plus a magnesium citrate/bisacodyl bowel cleansing regimen with a clear liquid diet and sodium phosphate solution regimen in children undergoing colonoscopy.

Methods: Children scheduled for a diagnostic colonoscopy, were randomly assigned to receive a prepackaged diet kit and a magnesium citrate/bisacodyl laxative (group 1), or clear liquids and sodium phosphate solution (group 2). The patients and their parents completed a questionnaire to evaluate acceptance of their assigned regimen before colonoscopy. The endoscopists, blinded to the type of bowel preparation, rated bowel cleansing.

Results: Sixty two children (28 males, 34 females) with mean age 12.5 years participated. Thirty six and 26 patients were in groups 1 and 2 respectively. Overall cleansing was rated significantly superior in group 1 compared to group 2 as was amount of retained feces (P = .013 for both). The overall frequency of reported side-effects was lower in group 1 than (83.3%, 30/36) than in group 2 (100.0%, 26/26) (P = 0.03). The preparations were otherwise equivalent in regards to compliance and patient tolerance.

Conclusions: Although both regimens were comparable in adequacy of colon visualization, preparation tolerance, side effects and compliance profile in this pilot study, the prepackaged diet kit with magnesium citrate/bisacodyl laxative resulted in superior colon cleansing.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Bisacodyl / pharmacology
  • Cathartics / pharmacology*
  • Child
  • Child, Preschool
  • Citric Acid / pharmacology
  • Colonoscopy*
  • Diet*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Organometallic Compounds / pharmacology
  • Patient Acceptance of Health Care
  • Patient Compliance*
  • Phosphates / adverse effects
  • Phosphates / pharmacology*
  • Pilot Projects
  • Prospective Studies
  • Safety
  • Taste
  • Treatment Outcome


  • Cathartics
  • Organometallic Compounds
  • Phosphates
  • Bisacodyl
  • Citric Acid
  • magnesium citrate
  • sodium phosphate