Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

J Biomed Sci. 2006 Mar;13(2):205-13. doi: 10.1007/s11373-005-9057-3. Epub 2006 Feb 3.


Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation*
  • Chromosomal Proteins, Non-Histone / physiology*
  • Humans
  • Microfilament Proteins
  • Mitosis*
  • Muscle Cells / cytology
  • Transcription, Genetic*


  • Chromosomal Proteins, Non-Histone
  • Microfilament Proteins
  • centromere protein F