A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes

Am J Obstet Gynecol. 2006 Feb;194(2):369-76. doi: 10.1016/j.ajog.2005.08.020.

Abstract

Objective: This study was undertaken to examine whether marijuana use affects in vitro fertilization and gamete intrafallopian transfer (IVF/GIFT).

Study design: Prospective study of 221 IVF/GIFT couples.

Results: Amount of lifetime heavy marijuana use adversely affected IVF/GIFT. Women smoking more than 90 times in their lifetime had 27% fewer oocytes retrieved (P = .03) and 1 fewer embryo transferred (P < .05). Women smoking marijuana more than 10 times in their lifetime had infants 17% (P = .01) smaller at birth. If men smoked marijuana 11 to 90 times in their lifetime, there was a 15% decrease in infant birth weight (P = .03); if this increased to more than 90 times, there was a 23% decrease (P = .01). Timing also played a role. Women smoking marijuana 1 year before IVF/GIFT had 25% fewer oocytes retrieved (P = .03), whereas couples had 28% (P = .04) fewer oocytes fertilized. Women and men who smoked in the past 15 years, had 12% (P = .04) and 16% (P = .03) smaller infants, respectively.

Conclusion: Both timing and amount of marijuana use negatively affected IVF/GIFT.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Birth Weight
  • Embryo Transfer
  • Female
  • Fertilization in Vitro / statistics & numerical data*
  • Gamete Intrafallopian Transfer / statistics & numerical data*
  • Humans
  • Infant, Newborn
  • Male
  • Marijuana Smoking / adverse effects*
  • Middle Aged
  • Pregnancy
  • Pregnancy Outcome
  • Prenatal Exposure Delayed Effects / epidemiology*
  • Prospective Studies
  • Spermatozoa / drug effects