Fibrovascular ingrowth as a cause of Ahmed glaucoma valve failure in children

Am J Ophthalmol. 2006 Feb;141(2):388-9. doi: 10.1016/j.ajo.2005.08.033.


Purpose: The purpose of this study is to document the presence of fibrovascular ingrowth into the Ahmed glaucoma valve (AGV) as a cause of AGV failure in the pediatric population.

Design: Retrospective case series.

Methods: Retrospective study of six children with histologically documented fibrovascular ingrowth of their AGV, with review of relevant demographic, clinical, and surgical factors.

Results: Six patients, two males and four females, with a mean age at AGV placement of 27.5 months (range 1 to 122) were identified with AGV failure, AGV removal, and subsequent histology documenting fibrovascular ingrowth into the valve chamber. Etiology of glaucoma included: trauma, aphakia, angle-closure, aniridia, and infantile. Mean time from AGV implantation to explantation was 23 months (range 6 to 65). Mean intraocular pressure at AGV explantation was 35 mm Hg (range 27 to 48).

Conclusions: Fibrovascular ingrowth of both the pediatric and adult size AGV occurs in children and should be considered in the presence of AGV failure.

MeSH terms

  • Child
  • Child, Preschool
  • Device Removal
  • Female
  • Fibroblasts / pathology*
  • Fibrosis
  • Glaucoma / surgery
  • Glaucoma Drainage Implants*
  • Humans
  • Infant
  • Intraocular Pressure
  • Lymphocytes / pathology
  • Macrophages / pathology
  • Male
  • Prosthesis Failure*
  • Prosthesis Implantation
  • Retrospective Studies