Abstract
Aging is the accumulation of diverse deleterious changes in the cells and tissues leading to increased risk of diseases. Oxidative stress is considered as a major risk factor and contributes to age related increase in DNA oxidation and DNA protein cross-links in central nervous system during aging. In the present study, we have evaluated the salubrious role of grape seed extract on accumulation of oxidative DNA damage products such as 8-OHdG and DNA protein cross-links in aged rats. Male albino rats of Wistar strain were divided into four groups: Group I, young control rats; Group II, young rats treated with grape seed extract (100 mg/kg b.wt.) for 30 days; Group III, aged control rats; Group IV, aged rats supplemented with grape seed extract (100 mg/kg b.wt.) for 30 days. Our results, thus, revealed that grape seed extract has inhibiting effect on the accumulation of age-related oxidative DNA damages in spinal cord and in various brain regions such as cerebral cortex, striatum and hippocampus.
MeSH terms
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8-Hydroxy-2'-Deoxyguanosine
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Aging / drug effects*
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Aging / metabolism
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Animals
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Antioxidants / pharmacology
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Antioxidants / therapeutic use
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Brain / drug effects
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Brain / metabolism
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Brain / physiopathology
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Cellular Senescence / drug effects*
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Cellular Senescence / physiology
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Central Nervous System / drug effects*
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Central Nervous System / metabolism
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Central Nervous System / physiopathology
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DNA / drug effects
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DNA Damage / drug effects*
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DNA Damage / physiology
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Deoxyguanosine / analogs & derivatives
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Deoxyguanosine / metabolism
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Flavonoids / pharmacology
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Flavonoids / therapeutic use
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Grape Seed Extract
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Male
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Oxidative Stress / drug effects*
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Oxidative Stress / physiology
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Phenols / pharmacology
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Phenols / therapeutic use
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Polyphenols
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Proanthocyanidins / pharmacology*
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Proanthocyanidins / therapeutic use
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Rats
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Rats, Wistar
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Spinal Cord / drug effects
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Spinal Cord / metabolism
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Spinal Cord / physiopathology
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Treatment Outcome
Substances
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Antioxidants
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Flavonoids
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Grape Seed Extract
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Grape Seed Proanthocyanidins
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Phenols
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Plant Extracts
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Polyphenols
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Proanthocyanidins
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8-Hydroxy-2'-Deoxyguanosine
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DNA
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Deoxyguanosine