Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol

Nutrition. 2006 Feb;22(2):128-35. doi: 10.1016/j.nut.2005.04.016.


Objective: The objective of the present study was to verify the effect of a dietary oil, consisting mainly of diacylglycerol (DAG) oil, in a typical meal on postprandial changes in serum triacylglycerol (TAG) and remnant-like particle cholesterol (RLP-C) compared with dietary triacylglycerol (TAG) oil.

Methods: In a double-blind, randomized, crossover design, 43 healthy Japanese men and women ingested test meals (2093 kJ of energy, 30 g of protein, 19 g of lipids, and 51 g of carbohydrates) containing 10 g of DAG oil (DAG meal) or TAG oil (TAG meal). Blood samples were collected in a fasting state (0 h) and at 2, 3, 4, and 6 h after ingestion of the meal.

Results: Postprandial TAG, RLP-C, and chylomicron TAG concentrations were significantly lower after the DAG meal compared with the TAG meal. In 29 subjects with fasting serum TAG levels of at least 1.13 mmol/L (100 mg/dL), differences in postprandial serum changes between meal types were even more remarkable and the incremental areas under the response curve (0 to 6 h) for serum TAG and RLP-C concentrations after the DAG meal were significantly smaller than those after the TAG meal.

Conclusions: These results suggest that DAG oil in the daily diet is useful for the prevention of postprandial hyperlipidemia and related disorders.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Area Under Curve
  • Cholesterol / blood*
  • Chylomicrons / blood
  • Cross-Over Studies
  • Diglycerides / administration & dosage
  • Diglycerides / pharmacokinetics*
  • Double-Blind Method
  • Female
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / prevention & control*
  • Lipids / blood*
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Postprandial Period / drug effects
  • Postprandial Period / physiology
  • Triglycerides / administration & dosage
  • Triglycerides / blood
  • Triglycerides / pharmacokinetics*


  • Chylomicrons
  • Diglycerides
  • Lipids
  • Lipoproteins
  • Triglycerides
  • remnant-like particle cholesterol
  • Cholesterol