IL-31: a new link between T cells and pruritus in atopic skin inflammation

J Allergy Clin Immunol. 2006 Feb;117(2):411-7. doi: 10.1016/j.jaci.2005.10.033.


Background: IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor.

Objective: To investigate the role of human IL-31 in pruritic and nonpruritic inflammatory skin diseases.

Methods: The expression of IL-31 was analyzed by quantitative real-time PCR in skin samples of healthy individuals and patients with chronic inflammatory skin diseases. Moreover, IL-31 expression was analyzed in nonlesional skin of atopic dermatitis patients after allergen or superantigen exposure, as well as in stimulated leukocytes. The tissue distribution of the IL-31 receptor heterodimer was investigated by DNA microarray analysis.

Results: IL-31 was significantly overexpressed in pruritic atopic compared with nonpruritic psoriatic skin inflammation. Highest IL-31 levels were detected in prurigo nodularis, one of the most pruritic forms of chronic skin inflammation. In vivo, staphylococcal superantigen rapidly induced IL-31 expression in atopic individuals. In vitro, staphylococcal enterotoxin B but not viruses or T(H)1 and T(H)2 cytokines induced IL-31 in leukocytes. In patients with atopic dermatitis, activated leukocytes expressed significantly higher IL-31 levels compared with control subjects. IL-31 receptor A showed most abundant expression in dorsal root ganglia representing the site where the cell bodies of cutaneous sensory neurons reside.

Conclusion: Our findings provide a new link among staphylococcal colonization, subsequent T-cell recruitment/activation, and pruritus induction in patients with atopic dermatitis. Taken together, these findings show that IL-31 may represent a novel target for antipruritic drug development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dermatitis, Atopic / immunology*
  • Dermatitis, Atopic / metabolism
  • Dermatitis, Atopic / physiopathology
  • Ganglia, Spinal / metabolism
  • Humans
  • Interleukins / metabolism*
  • Lymphocyte Activation
  • Prurigo / immunology
  • Prurigo / metabolism
  • Pruritus / immunology*
  • Pruritus / metabolism
  • Pruritus / physiopathology
  • Psoriasis / immunology
  • Psoriasis / metabolism
  • Receptors, Interleukin / metabolism
  • Staphylococcus aureus / immunology
  • Superantigens / immunology
  • T-Lymphocytes / immunology*
  • Up-Regulation


  • IL31 protein, human
  • IL31RA protein, human
  • Interleukins
  • Receptors, Interleukin
  • Superantigens