Chromosome biology: the crux of the ring

Frank Uhlmann; Karl-Peter Hopfner

doi:10.1016/j.cub.2006.01.023

Chromosome biology: the crux of the ring

Curr Biol. 2006 Feb 7;16(3):R102-5. doi: 10.1016/j.cub.2006.01.023.

Authors

Frank Uhlmann¹, Karl-Peter Hopfner

Affiliation

¹ Lincoln's Inn Fields Laboratories, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

PMID: 16461262
DOI: 10.1016/j.cub.2006.01.023

Abstract

SMC proteins are key components of large ring-shaped chromosomal protein complexes, such as cohesin and condensin. New evidence supports the idea that these rings topologically encircle DNA. Hints also emerge as to what it may take for DNA to enter the ring.

Publication types

Review

MeSH terms

Adenosine Triphosphatases / metabolism*
Adenosine Triphosphate / metabolism
Animals
Cell Cycle Proteins / metabolism*
Chromosomal Proteins, Non-Histone / metabolism*
Chromosomes, Fungal / physiology*
Cohesins
DNA / metabolism*
DNA-Binding Proteins / metabolism*
Models, Biological*
Multiprotein Complexes / metabolism*
Nuclear Proteins / metabolism*
Schizosaccharomyces

Substances

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Multiprotein Complexes
Nuclear Proteins
condensin complexes
Adenosine Triphosphate
DNA
Adenosine Triphosphatases