Immune response to premalignancy: insights from patients with monoclonal gammopathy

Ann N Y Acad Sci. 2005 Dec;1062:22-8. doi: 10.1196/annals.1358.004.


Many patients with preneoplastic gammopathy remain clinically stable, in spite of the presence of multiple genomic abnormalities in tumor cells. Our hypothesis is that the development of clinical cancer depends not just on the genomic changes in tumor cells, but also their interactions with the host-tumor microenvironment. Recent studies have shown that the host immune system is capable of responding to preneoplastic cells. Improved understanding of this response may provide novel opportunities for early detection and immune prevention of cancer.

Publication types

  • Review

MeSH terms

  • Humans
  • Paraproteinemias / diagnosis
  • Paraproteinemias / immunology*
  • Paraproteinemias / pathology
  • Paraproteinemias / therapy
  • Precancerous Conditions / diagnosis
  • Precancerous Conditions / immunology*
  • Precancerous Conditions / pathology
  • Precancerous Conditions / therapy