Changes in immune responses to mite antigen sensitized through barrier-disrupted skin with CpG-oligodeoxynucleotide in mice

Biol Pharm Bull. 2006 Feb;29(2):385-7. doi: 10.1248/bpb.29.385.

Abstract

CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. We examined here the effect of CpG-ODN on the immune response to mite antigen sensitized through barrier-disrupted skin of human atopic dermatitis (AD) model mouse. Although sensitization with mite antigen induced Th2-dominant immune response, co-administration of CpG-ODN elicited Th1-predominant immune response. In terms of antigen-specific antibody production, the level of IgG2a was increased by CpG-ODN, but not in IgE. These results suggested that administration of CpG-ODN via skin is a simple strategy for patients with diseases like AD, which is characterized by Th2-dominated inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / pharmacology*
  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Antigens, Dermatophagoides / administration & dosage
  • Antigens, Dermatophagoides / immunology*
  • Cytokines / immunology
  • Dermatitis, Atopic / drug therapy
  • Dermatitis, Atopic / immunology*
  • Disease Models, Animal
  • Male
  • Mice
  • Mice, Inbred Strains
  • Oligodeoxyribonucleotides / administration & dosage
  • Oligodeoxyribonucleotides / pharmacology*
  • Oligodeoxyribonucleotides / therapeutic use
  • Skin / drug effects
  • Skin / immunology*
  • Spleen / cytology
  • Spleen / drug effects
  • Spleen / immunology
  • Th1 Cells / immunology
  • Th2 Cells / immunology

Substances

  • Adjuvants, Immunologic
  • Antigens, Dermatophagoides
  • CPG-oligonucleotide
  • Cytokines
  • Oligodeoxyribonucleotides