Abstract
CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. We examined here the effect of CpG-ODN on the immune response to mite antigen sensitized through barrier-disrupted skin of human atopic dermatitis (AD) model mouse. Although sensitization with mite antigen induced Th2-dominant immune response, co-administration of CpG-ODN elicited Th1-predominant immune response. In terms of antigen-specific antibody production, the level of IgG2a was increased by CpG-ODN, but not in IgE. These results suggested that administration of CpG-ODN via skin is a simple strategy for patients with diseases like AD, which is characterized by Th2-dominated inflammation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / pharmacology*
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Adjuvants, Immunologic / therapeutic use
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Animals
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Antigens, Dermatophagoides / administration & dosage
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Antigens, Dermatophagoides / immunology*
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Cytokines / immunology
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Dermatitis, Atopic / drug therapy
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Dermatitis, Atopic / immunology*
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Disease Models, Animal
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Male
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Mice
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Mice, Inbred Strains
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Oligodeoxyribonucleotides / administration & dosage
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Oligodeoxyribonucleotides / pharmacology*
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Oligodeoxyribonucleotides / therapeutic use
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Skin / drug effects
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Skin / immunology*
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Spleen / cytology
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Spleen / drug effects
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Spleen / immunology
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Th1 Cells / immunology
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Th2 Cells / immunology
Substances
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Adjuvants, Immunologic
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Antigens, Dermatophagoides
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CPG-oligonucleotide
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Cytokines
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Oligodeoxyribonucleotides