Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult

Am J Clin Oncol. 2006 Feb;29(1):102-3. doi: 10.1097/01.coc.0000160067.48292.70.


Although it is recognized that aggressive soft tissue sarcomas may give rise to cardiac metastases, these manifestations are usually late and clinically silent, being the prevailing finding in exceptional cases. This report describes the occurrence of a massive cardiac metastasis at diagnosis of leg rhabdomyosarcoma in a middle-age adult. This manifestation was the cause of rapidly progressive congestive heart failure and, together with the unusual occurrence of autoimmune thrombocytopenia, led to difficult patient care with a significantly negative influence on the outcome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Comorbidity
  • Fatal Outcome
  • Heart Failure / etiology
  • Heart Neoplasms / complications
  • Heart Neoplasms / secondary*
  • Humans
  • Leg / pathology
  • Male
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy
  • Rhabdomyosarcoma / complications
  • Rhabdomyosarcoma / secondary*
  • Soft Tissue Neoplasms / pathology*