Genetic susceptibility to coronary artery disease: from promise to progress

Nat Rev Genet. 2006 Mar;7(3):163-73. doi: 10.1038/nrg1805.


Family history is an important independent risk factor for coronary artery disease (CAD), and identification of susceptibility genes for this common, complex disease is a vital goal. Although there has been considerable success in identifying genetic variants that influence well-known risk factors, such as cholesterol levels, progress in unearthing novel CAD genes has been slow. However, advances are now being made through the application of large-scale, systematic, genome-wide approaches. Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer.

Publication types

  • Review

MeSH terms

  • Animals
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / immunology
  • Coronary Artery Disease / pathology
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation*
  • Genome, Human / genetics*
  • Humans
  • Inflammation / genetics
  • Inflammation / immunology
  • Inflammation / pathology
  • Sequence Analysis, DNA / methods
  • Sequence Analysis, DNA / trends*