Abstract
Two novel axially substituted phthalocyanines, namely bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon (IV) (1) and its N-methylated derivative 2, have been synthesized. The dicationic phthalocyanine 2 is non-aggregated in water and exhibits good photophysical properties. The non-covalent BSA conjugates of these compounds have also been prepared. Compound 2 and the conjugate 2-BSA show extremely high photodynamic activities toward B16 melanoma cancer cell lines. The corresponding 50% growth-inhibitory (IC50) ratios are 33 and 38 nM, respectively.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cattle
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Drug Screening Assays, Antitumor
-
In Vitro Techniques
-
Indoles / chemical synthesis*
-
Indoles / chemistry
-
Indoles / pharmacology*
-
Mice
-
Molecular Structure
-
Organosilicon Compounds / chemical synthesis*
-
Organosilicon Compounds / chemistry
-
Organosilicon Compounds / pharmacology*
-
Photosensitizing Agents / chemical synthesis*
-
Photosensitizing Agents / chemistry
-
Photosensitizing Agents / pharmacology*
-
Serum Albumin, Bovine / chemistry*
-
Stereoisomerism
Substances
-
Indoles
-
Organosilicon Compounds
-
Photosensitizing Agents
-
bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon
-
silicon phthalocyanine
-
Serum Albumin, Bovine