Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach

J Biochem Mol Biol. 2006 Jan 31;39(1):1-8. doi: 10.5483/bmbrep.2006.39.1.001.


Helicobacter pylori is the definitive carcinogen for stomach cancer and is known to induce proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1(IL-1) in the stomach. Based on our findings that TNF-alpha is an endogenous tumor promoter, we identified the TNFalpha inducing protein (Tipalpha) gene family, and confirmed Tipalpha and HP-MP1 as new carcinogenic proteins of H. pylori.Tipalpha protein is unique to H. pylori, and this paper shows the strong tumor promoting activity of Tipalpha gene family, in cooperation with Ras protein and its mechanisms of action in relation to NF-kappaB activation, and discusses the carcinogenic role of Tipalpha in stomach cancer. Our recent finding showing that penicillin-binding proteins of other bacteria are weak homologues of Tipalpha is also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Cell Transformation, Neoplastic*
  • Dimerization
  • Helicobacter Infections*
  • Helicobacter pylori / metabolism*
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Multigene Family
  • NF-kappa B / metabolism
  • Penicillin-Binding Proteins / chemistry
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Stomach / microbiology*
  • Stomach / pathology
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / physiopathology
  • Tumor Necrosis Factor-alpha / metabolism*
  • ras Proteins / metabolism


  • Bacterial Proteins
  • NF-kappa B
  • Penicillin-Binding Proteins
  • Tipalpha protein, Helicobacter pylori
  • Tumor Necrosis Factor-alpha
  • ras Proteins