Results of trabeculectomy with adjunctive intraoperative mitomycin C in Chinese patients with glaucoma

Ophthalmic Surg Lasers Imaging. Jan-Feb 2006;37(1):33-41.

Abstract

Background and objective: To report the results of trabeculectomy with adjunctive intraoperative mitomycin C in Chinese patients with glaucoma.

Patients and methods: The medical records of Chinese patients who received trabeculectomy with intraoperative mitomycin C from 1992 to 1998 were retrospectively reviewed. A "successful" trabeculectomy was defined as one after which the intraocular pressure (IOP) could be controlled to between 5 and 21 mm Hg, inclusive, with no more than 3 glaucoma medications.

Results: One hundred fourteen trabeculectomies in 105 eyes of 90 patients were retrospectively reviewed. Mean age +/- standard deviation was 48.1 +/- 21.9 years. Primary open-angle glaucoma (43.0%) and angle-closure glaucoma (27.2%) were the most common diagnoses leading to trabeculectomy. The mean follow-up +/- standard deviation was 29.6 +/- 18.6 months (range, 6 to 92 months). The overall success rate at the last follow-up was 73.7% (84 of 114 trabeculectomies).

Conclusions: Trabeculectomy with mitomycin C is a safe and effective procedure for the control of IOP in Chinese patients with glaucoma.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group*
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Glaucoma / drug therapy
  • Glaucoma / physiopathology
  • Glaucoma / surgery*
  • Hong Kong / epidemiology
  • Humans
  • Incidence
  • Intraocular Pressure
  • Intraoperative Period
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Mitomycin / therapeutic use*
  • Nucleic Acid Synthesis Inhibitors / administration & dosage
  • Nucleic Acid Synthesis Inhibitors / therapeutic use*
  • Ophthalmic Solutions
  • Postoperative Complications / epidemiology
  • Postoperative Complications / prevention & control*
  • Retrospective Studies
  • Trabeculectomy / methods*
  • Treatment Outcome

Substances

  • Nucleic Acid Synthesis Inhibitors
  • Ophthalmic Solutions
  • Mitomycin