Rejuvenating exhausted T cells during chronic viral infection

Taku Okazaki; Tasuku Honjo

doi:10.1016/j.cell.2006.01.022

Rejuvenating exhausted T cells during chronic viral infection

Cell. 2006 Feb 10;124(3):459-61. doi: 10.1016/j.cell.2006.01.022.

Authors

Taku Okazaki¹, Tasuku Honjo

Affiliation

¹ Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto, 606-8501, Japan.

PMID: 16469690
DOI: 10.1016/j.cell.2006.01.022

Abstract

In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.

Publication types

Comment

MeSH terms

Animals
Antigens, Surface / immunology
Antigens, Surface / metabolism
Apoptosis Regulatory Proteins / immunology
Apoptosis Regulatory Proteins / metabolism
B7-1 Antigen / immunology
B7-1 Antigen / metabolism
B7-H1 Antigen
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism
Chronic Disease
Membrane Glycoproteins / immunology
Membrane Glycoproteins / metabolism
Mice
Models, Immunological
Peptides / immunology
Peptides / metabolism
Programmed Cell Death 1 Receptor
Signal Transduction
Virus Diseases / immunology*
Virus Diseases / metabolism

Substances

Antigens, Surface
Apoptosis Regulatory Proteins
B7-1 Antigen
B7-H1 Antigen
Cd274 protein, mouse
Membrane Glycoproteins
Pdcd1 protein, mouse
Peptides
Programmed Cell Death 1 Receptor