Rejuvenating Exhausted T Cells During Chronic Viral Infection

Cell. 2006 Feb 10;124(3):459-61. doi: 10.1016/j.cell.2006.01.022.

Abstract

In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Surface / immunology
  • Antigens, Surface / metabolism
  • Apoptosis Regulatory Proteins / immunology
  • Apoptosis Regulatory Proteins / metabolism
  • B7-1 Antigen / immunology
  • B7-1 Antigen / metabolism
  • B7-H1 Antigen
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • Chronic Disease
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / metabolism
  • Mice
  • Models, Immunological
  • Peptides / immunology
  • Peptides / metabolism
  • Programmed Cell Death 1 Receptor
  • Signal Transduction
  • Virus Diseases / immunology*
  • Virus Diseases / metabolism

Substances

  • Antigens, Surface
  • Apoptosis Regulatory Proteins
  • B7-1 Antigen
  • B7-H1 Antigen
  • Cd274 protein, mouse
  • Membrane Glycoproteins
  • Pdcd1 protein, mouse
  • Peptides
  • Programmed Cell Death 1 Receptor