TOR Signaling in Growth and Metabolism

Cell. 2006 Feb 10;124(3):471-84. doi: 10.1016/j.cell.2006.01.016.

Abstract

The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to environmental cues. Here, highlighting contributions from studies in model organisms, we review mammalian TOR complexes and the signaling branches they mediate. TOR is part of two distinct multiprotein complexes, TOR complex 1 (TORC1), which is sensitive to rapamycin, and TORC2, which is not. The physiological consequences of mammalian TORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism
  • Animals
  • Cell Proliferation
  • Humans
  • Memory / physiology
  • Models, Biological
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction
  • TOR Serine-Threonine Kinases

Substances

  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Protein-Serine-Threonine Kinases
  • target of rapamycin protein, S cerevisiae