Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas

Oncogene. 1991 May;6(5):765-70.


Cytogenetic analysis of eight human hepatoma-derived cell lines and one primary hepatocellular carcinoma biopsy revealed multiple chromosome abnormalities; however, only chromosome 1 was consistently affected by rearrangements. Pseudopolysomy 1 as well as chromosome 1 deletions and/or translocations that resulted in loss of the distal 1p region from at least one copy of chromosome 1 were observed in all but one of the cell lines analysed. Molecular analyses of tumor-derived and normal genomic DNA from six cases of hepatocellular carcinoma and from two of hepatoblastoma, using a panel of chromosome 1p-specific DNA probes indicated allelic loss in the distal 1p region in five of the six hepatocellular carcinomas but not in either hepatoblastoma. These results suggest the location of a gene in the distal 1p region whose functional loss may be involved in hepatocellular carcinogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / microbiology
  • Cell Line
  • Chromosome Aberrations*
  • Chromosome Disorders*
  • Chromosomes, Human, Pair 1*
  • DNA Probes
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / isolation & purification
  • Gene Rearrangement
  • Hepatitis B virus / genetics
  • Hepatitis B virus / isolation & purification
  • Heterozygote*
  • Humans
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / microbiology
  • Translocation, Genetic


  • DNA Probes
  • DNA, Neoplasm