Inflammatory myofibroblastic tumor of the larynx

Head Neck. 2006 Apr;28(4):369-72. doi: 10.1002/hed.20413.


Background: Inflammatory myofibroblastic tumor, composed of myofibroblastic spindle cells with acute and chronic inflammatory cells, is an unusual, benign solid mass that mimics a neoplastic process.

Methods: We report a rare case of a patient with a laryngeal inflammatory myofibroblastic tumor. Laryngoscopy demonstrated a submucosal mass involving the right false cord. The mass was a well-enhanced supraglottic lesion on CT scan. It showed medially high signal intensity and peripherally low signal intensity on T2-weighted MR images, and it displayed a high magnetization transfer ratio; before surgery, it was believed to be a malignant tumor. Laryngoscopic biopsy was performed. Pathologic features of the specimen were diagnostic for inflammatory myofibroblastic tumor.

Results: Steroid therapy was chosen for further treatment. No recurrence was observed for 4 years.

Conclusion: In patients with chronic hoarseness who have a malignant-looking submucosal laryngeal mass, inflammatory myofibroblastic tumor should be considered. Conservative surgery and steroid treatment are advocated because of laryngeal preservation.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Biopsy
  • Diagnostic Imaging
  • Female
  • Granuloma, Plasma Cell / pathology*
  • Granuloma, Plasma Cell / therapy
  • Hoarseness / etiology
  • Humans
  • Laryngeal Neoplasms / pathology*
  • Laryngeal Neoplasms / therapy
  • Laryngoscopy
  • Larynx / pathology
  • Middle Aged


  • Adrenal Cortex Hormones