Molecular mechanism of herbs in human lung cancer cells

J Med Assoc Thai. 2005 Nov;88(11):1725-34.

Abstract

Herbs have been considered natural and valuable sources for anticancer drug discovery. Herbal medicine has been prescribed in many countries over centuries for treating various diseases including infectious and malignant diseases. Nowadays, many of the drugs that have been used for treatment of malignant diseases are derived from natural products such as Taxol, a natural product isolated initially from Pacific Yew (Taxus brevifolia). This review article describes research on molecular mechanisms, especially cytotoxic effect of natural products from plant sources, primarily preclinical studies, involving human lung cancer cells in vitro for providing more knowledge and issues for potential drug development from medicinal herbs in the future.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Apoptosis / drug effects
  • Herbal Medicine*
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / physiopathology
  • Plants, Medicinal*
  • Signal Transduction / drug effects

Substances

  • Antineoplastic Agents, Phytogenic