[Autophagy in cell survival and death]

J Soc Biol. 2005;199(3):233-41. doi: 10.1051/jbio:2005024.
[Article in French]

Abstract

Macroautophagy hereafter referred to as autophagy is a major lysosomal catabolic pathway for macromolecules and organelles conserved in eukaryotic cells. The discovery of the molecular basis of autophagy has uncovered its importance during development, life extension and in pathologies such as cancer, certain forms of myopathies and neurodegenerative diseases. Autophagy is a cell survival mechanism during starvation that is controlled by amino acids. Starvation-induced autophagy is an anti-apoptotic mechanism. However autophagy is also an alternative to apoptosis through autophagic cell death. In many situations apoptosis and autophagy can both contribute to cell dismantlement.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Amino Acids / physiology
  • Animals
  • Apoptosis / physiology
  • Autophagy / physiology*
  • Cell Survival / physiology*
  • Eukaryotic Cells / cytology
  • Hormones / physiology
  • Humans
  • Lysosomes / physiology
  • Mitochondria / physiology
  • Models, Biological
  • Muscular Diseases / pathology
  • Neoplasms / pathology
  • Neurodegenerative Diseases / pathology
  • Phosphatidylinositol 3-Kinases / physiology
  • Protein Kinases / physiology
  • Starvation / physiopathology
  • TOR Serine-Threonine Kinases

Substances

  • Amino Acids
  • Hormones
  • Protein Kinases
  • Phosphatidylinositol 3-Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases