Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes

Biochim Biophys Acta. 1991 Jun 13;1089(2):269-72. doi: 10.1016/0167-4781(91)90023-f.

Abstract

cDNAs encoding three protein phosphatases, termed PP2Bw (Da Cruz e Silva, E.F. and Cohen, P.T.W. (1989) Biochim. Biophys. Acta 1009, 293-296), PPZ1 and PPZ2 that have been isolated from a Clontech 'rabbit brain' library are shown to be Saccharomyces cerevisiae clones. PPZ1 and PPZ2 are two novel yeast phosphatases showing 93% amino acid sequence identity to one another. PPZ1 shows approx. 60% sequence identity to S. cerevisiae or mammalian PP1 and approx. 40% identity to S. cerevisiae or mammalian PP2A. These and other observations suggest that the two isoforms of PPZ have functions distinct from those of PP1.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • DNA / genetics
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Phosphoprotein Phosphatases / genetics*
  • Rabbits
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae / genetics
  • Sequence Homology, Nucleic Acid

Substances

  • DNA
  • Phosphoprotein Phosphatases

Associated data

  • GENBANK/M75974
  • GENBANK/M75975
  • GENBANK/X57930
  • GENBANK/X57931
  • GENBANK/X57932
  • GENBANK/X57933
  • GENBANK/X57934
  • GENBANK/X57935
  • GENBANK/X61289
  • GENBANK/X61290