Differential patterns of multisensory interactions in core and belt areas of human auditory cortex

Neuroimage. 2006 May 15;31(1):294-300. doi: 10.1016/j.neuroimage.2005.12.038. Epub 2006 Feb 9.


The auditory cortex is anatomically segregated into a central core and a peripheral belt region, which exhibit differences in preference to bandpassed noise and in temporal patterns of response to acoustic stimuli. While it has been shown that visual stimuli can modify response magnitude in auditory cortex, little is known about differential patterns of multisensory interactions in core and belt. Here, we used functional magnetic resonance imaging and examined the influence of a short visual stimulus presented prior to acoustic stimulation on the spatial pattern of blood oxygen level-dependent signal response in auditory cortex. Consistent with crossmodal inhibition, the light produced a suppression of signal response in a cortical region corresponding to the core. In the surrounding areas corresponding to the belt regions, however, we found an inverse modulation with an increasing signal in centrifugal direction. Our data suggest that crossmodal effects are differentially modulated according to the hierarchical core-belt organization of auditory cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Attention / physiology*
  • Auditory Cortex / physiology*
  • Auditory Pathways / physiology*
  • Brain Mapping*
  • Cell Communication / physiology*
  • Dominance, Cerebral / physiology
  • Female
  • Flicker Fusion / physiology*
  • Hemodynamics / physiology
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging*
  • Male
  • Neural Analyzers
  • Neural Inhibition / physiology
  • Oxygen / blood*
  • Photic Stimulation
  • Synaptic Transmission / physiology*


  • Oxygen