T-sing progenitors to commit

Trends Immunol. 2006 Mar;27(3):125-31. doi: 10.1016/j.it.2006.01.006. Epub 2006 Feb 10.


T-cell development in the thymus is a complex and highly regulated process. During the process of differentiation from multipotent progenitor cells to mature T cells, proliferation, restriction of lineage potential, TCR gene rearrangements and selection events occur, all accompanied by changes in gene expression. A comprehensive understanding of thymocyte differentiation remains to be established. Two related, key issues have received much attention recently: the nature of the thymus seeding cell and the regulation of T-cell lineage commitment. Here we review the perspectives of different researchers working both on murine and human T-cell development and argue that a true T-cell commitment factor might not be required because of the unique properties of the thymus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • Bone Marrow Cells / physiology
  • Cell Lineage
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Lymphopoiesis*
  • Signal Transduction
  • Stem Cells / cytology*
  • T-Lymphocytes / cytology*
  • Thymus Gland / cytology*