Nuclear receptors, bile-acid detoxification, and cholestasis

Lancet. 2006 Feb 11;367(9509):454-6. doi: 10.1016/S0140-6736(06)68156-7.
No abstract available

MeSH terms

  • Animals
  • Bile Acids and Salts / biosynthesis*
  • Bile Acids and Salts / metabolism
  • Chenodeoxycholic Acid / analogs & derivatives*
  • Chenodeoxycholic Acid / pharmacology
  • Cholestasis / drug therapy*
  • Cholestasis / etiology
  • Cholestasis / metabolism
  • DNA-Binding Proteins / drug effects*
  • DNA-Binding Proteins / physiology
  • Enzyme Inhibitors / adverse effects
  • Enzyme Inhibitors / therapeutic use*
  • Homeostasis / drug effects
  • Humans
  • Mice
  • Pregnane X Receptor
  • Rats
  • Receptors, Cytoplasmic and Nuclear / drug effects*
  • Receptors, Cytoplasmic and Nuclear / physiology
  • Receptors, Steroid / drug effects*
  • Receptors, Steroid / physiology
  • Rifampin / adverse effects
  • Rifampin / therapeutic use*
  • Transcription Factors / drug effects*
  • Transcription Factors / physiology

Substances

  • Bile Acids and Salts
  • DNA-Binding Proteins
  • Enzyme Inhibitors
  • Pregnane X Receptor
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Transcription Factors
  • obeticholic acid
  • farnesoid X-activated receptor
  • Chenodeoxycholic Acid
  • Rifampin