MK-801 prevents chemical kindling induced by pentylenetetrazol in rats

Eur J Pharmacol. 1991 Feb 14;193(3):363-5. doi: 10.1016/0014-2999(91)90152-g.

Abstract

The repeated administration of pentylenetetrazol (PTZ) at a subconvulsant dose (30 mg/kg i.p., three times a week for nine weeks) produced kindling in 90% of rats under treatment. Pretreatment with the N-methyl-D-aspartate receptor antagonist, MK-801 (1 mg/kg i.p., 40 min before PTZ), prevented the behavioral manifestation (i.e. motor seizures) as well as the development of kindling. In fact, convulsions were not observed in rats pretreated with MK-801 either during the chronic PTZ administration or when challenged with PTZ three and 10 days after completion of the chronic treatment. The results suggest an involvement of excitatory amino acid neurotransmission in PTZ kindling.

MeSH terms

  • Amino Acids / physiology
  • Animals
  • Dizocilpine Maleate / administration & dosage
  • Dizocilpine Maleate / pharmacology*
  • Dizocilpine Maleate / therapeutic use
  • Drug Administration Schedule
  • Injections, Intraperitoneal
  • Kindling, Neurologic / drug effects*
  • Male
  • Pentylenetetrazole / administration & dosage
  • Pentylenetetrazole / toxicity*
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Seizures / chemically induced
  • Seizures / prevention & control
  • Synaptic Transmission / physiology
  • Time Factors
  • gamma-Aminobutyric Acid / physiology

Substances

  • Amino Acids
  • Receptors, N-Methyl-D-Aspartate
  • gamma-Aminobutyric Acid
  • Dizocilpine Maleate
  • Pentylenetetrazole