Photorefractive keratectomy with intraoperative mitomycin-C application

J Cataract Refract Surg. 2005 Dec;31(12):2293-8. doi: 10.1016/j.jcrs.2005.05.027.


Purpose: To evaluate the efficacy and safety of photorefractive keratectomy (PRK) with intraoperative application of mitomycin-C (MMC).

Setting: Yonsei Eye Center, Seoul, South Korea.

Methods: This retrospective noncomparative case series included 536 patients (1011 eyes) who had had PRK with intraoperative application of MMC using the Nidek EC-5000 excimer laser. Preoperative and postoperative best spectacle-corrected and uncorrected visual acuities, spherical equivalent (SE) refraction, corneal haze graded by slitlamp biomicroscopy, and endothelial cell density measured by specular microscopy were evaluated.

Results: The mean preoperative SE was -7.82 diopters (D) +/- 2.64 (SD); 72% of eyes (732) were more than -6.00 D, and 28% (287) were more than -9.00 D. The mean follow-up was 13 months (range 6 to 27 months). Six months postoperatively, the mean postoperative SE was -0.14 +/- 0.62 D; 86% were within +/-0.50 D and 93% were within +/-1.00 D of desired refraction. Eighty-six percent had 20/20 or better visual acuity, and 98% were 20/40 or better. Regression of more than 1.00 D occurred in 78 eyes (7.6%), and it was more common in eyes with a preoperative SE of -9.00 D or worse (18%). Haze occurred in 32 eyes (3.17%), but in most cases it was limited to grade 1. Grades 2 and 3 haze occurred in 3 eyes and 2 eyes, respectively. The postoperative endothelial cell density measured by specular microscopy did not show a significant difference from preoperative measurements. Delayed epithelial healing was observed in 2 eyes.

Conclusion: Photorefractive keratectomy with intraoperative application of MMC was a safe procedure that produced excellent visual outcomes with few complications.

MeSH terms

  • Adult
  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / adverse effects
  • Combined Modality Therapy
  • Cornea / drug effects*
  • Cornea / surgery*
  • Female
  • Humans
  • Intraoperative Care
  • Lasers, Excimer
  • Male
  • Microscopy, Acoustic
  • Middle Aged
  • Mitomycin / administration & dosage*
  • Mitomycin / adverse effects
  • Myopia / surgery*
  • Photorefractive Keratectomy / methods*
  • Refraction, Ocular
  • Retrospective Studies
  • Visual Acuity


  • Antibiotics, Antineoplastic
  • Mitomycin