How to decrease p27Kip1 levels during tumor development

Cancer Cell. 2006 Feb;9(2):75-6. doi: 10.1016/j.ccr.2006.01.020.

Abstract

p27Kip1, a cyclin-cdk inhibitor, is a tumor suppressor. An overwhelming amount of data correlate p27 abundance to tumor prognosis in humans. Mouse models have supported the importance of decreasing p27 to tumor incidence. Inactivation of most tumor suppressors occurs at the level of gene mutation or silencing, but p27 is regulated posttranscriptionally, and how its level is reduced in cancer is largely unknown. Reports on a series of allelic mice with p27 mutations affecting different posttranscriptional regulatory pathways are emerging and being used to examine which pathways are necessary for p27 turnover associated with tumor development, with surprising results.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase Inhibitor p27 / metabolism*
  • Gene Expression Regulation, Neoplastic*
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • S-Phase Kinase-Associated Proteins / metabolism

Substances

  • S-Phase Kinase-Associated Proteins
  • Cyclin-Dependent Kinase Inhibitor p27