Gene regulatory networks and the determination of lymphoid cell fates

Curr Opin Immunol. 2006 Apr;18(2):116-20. doi: 10.1016/j.coi.2006.01.014. Epub 2006 Feb 10.


Considerable progress has been achieved in the identification and analysis of regulatory molecules that orchestrate B and T cell fate determination. IL-7 and Notch signaling appear to represent analogous pathways that direct B and T cell fates, respectively. For the B lineage, it is possible to assemble the various signaling components and transcription factors into a coherent gene regulatory network. At present, it is not possible to assemble an equivalently precise network for the T lineage as fewer components have been analyzed and their connectivity remains to be more fully explored. However, the ability to manipulate T cell development in a simple culture system using Notch ligand-expressing stromal cells is greatly facilitating analysis of this pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / immunology*
  • Interleukin-7 / immunology
  • Lymphocyte Activation / genetics
  • Lymphocyte Activation / immunology
  • Lymphocytes / immunology*
  • Receptors, Notch / immunology
  • Signal Transduction / immunology


  • Interleukin-7
  • Receptors, Notch